Effect of operating conditions and physico–chemical properties on the wet granulation kinetics in high shear mixer
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چکیده
منابع مشابه
Experimental Studies on the Effects of Process Parameters on Granule Properties in a Conical High Shear Granulator
Experimental work was carried out to investigate the influence of impeller speed, granulation time, binder mass and their interactions on granule size distribution, mean size and binder content distribution in a conical high shear granulator. It was observed that the response of high shear granulation to changes in process parameters varies significantly from one operating condition to anot...
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A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...
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تاریخ انتشار 2008